About 14-3-3 epsilon
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

About Alexa Fluor 405
Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to V450 (BD Biosciences), Vio®Blue® (Miltenyi Biotec), Cascade Blue® (ThermoFisher Scientific), Pacific Blue® (ThermoFisher Scientific). Alexa 405 is most commonly used in flow cytometery, and fluorescence microscopy applications.