HAMP / Unconjugated /
Product Details
| Description | Rabbit polyclonal antibody to HEPCIDIN is also known as LEAP1 whose expression can be detected in the tonsils and lungs but it is highly expressive in the liver. It is found in the apical cortex. This protein extensively acts by promoting endocytosis and degradation of ferroportin leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. It controls the major flows of iron into plasma: absorption of dietary iron in the intestine and recycling of iron by macrophages, which phagocytose old erythrocytes, other cells and mobilization of stored iron from hepatocytes. | |
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| Conjugate | Unconjugated | |
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| Target Species | Human, Mouse, Rat | |
| Applications | ELISA, IHC-P, WB | |
| Supplier | Biorbyt | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About HAMP
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]
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325 HAMP antibodies from over 14 suppliers available with over 28 conjugates.
