Axin-2 / Unconjugated /

Product Details
Description Rabbit polyclonal antibody to AXIN2
Conjugate Unconjugated
Clone
Target Species Human, Mouse, Rat
Applications IF, ICC, WB
Supplier Biorbyt
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About Axin-2
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
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289 Axin-2 antibodies from over 17 suppliers available with over 45 conjugates.

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