CD124 / Unconjugated /

Product Details
Description Produced in rabbits immunized with purified, recombinant Human IL4R / CD124 (rh IL4R; Catalog#10402-H08H; NP_000409.1; Met 1-His 232). IL4R / CD124 specific IgG was purified by Human IL4R / CD124 affinity chromatography.
Conjugate Unconjugated
Clone
Target Species Human
Applications ELISA
Supplier Sino Biological
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About CD124
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
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