F13A1 / Unconjugated /

Product Details
Description Anti-Factor XIIIa Rabbit Monoclonal Antibody tested for Flow Cytometry, IF, IHC, ICC, WB in Human.
Conjugate Unconjugated
Clone
Target Species Human
Applications FC, IF, ICC, WB, IHC
Supplier Boster Biological Technology
Catalog # Sign in to view product details, citations, and spectra
Size
Price
Antigen
Host
Isotype
About F13A1
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Experiment Design Tools
Conjugation Options

Pair this antibody with compatibility secondary antibodies, and conjugation kits and services:

Panel Builders

Looking to design a Microscopy or Flow Cytometry experiment?

Validation References
Additional
Sources
Reviews & Ratings
Looking for more options?

248 F13A1 antibodies from over 11 suppliers available with over 14 conjugates.

Supplier Page
 Compare