Synapsin IIa Polyclonal / Unconjugated /

Product Details
Description This detects ~74 and ~54 kDa proteins, corresponding to the apparent molecular masses of synapsin IIa and IIb on SDS-PAGE immunoblots, in samples from mouse and rat origins.
Conjugate Unconjugated
Clone
Target Species Mouse, Rat
Applications WB, IP
Supplier Novus Biologicals
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About Synapsin IIa
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014]
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Validation References
PMID 26280760
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