SENP5 Polyclonal / Unconjugated /
Product Details
| Description | A 50 kDa band is observed. Molecular weights observed may vary, depending isoform(s) present in the lysate. The antibody should recognize SENP5 isoforms containing the immunogen sequence (CNRKPFINREITNYRARH) used to make the antibody. Isoform sizes from 163-755 amino acids have been described for SENP5. Researchers are encouraged to BLAST the sequence (NCBI.NIH.GOV) to gain additional information. | |
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| Conjugate | Unconjugated | |
| Clone | ||
| Target Species | Human, Mouse | |
| Applications | WB | |
| Supplier | Novus Biologicals | |
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About SENP5
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
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