SELT Polyclonal / Unconjugated /

Product Details
Description Specificity of human SELT antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
Conjugate Unconjugated
Clone
Target Species Human
Applications ICC, IF, IHC-P, IHC
Supplier Novus Biologicals
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About SELT
This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017]
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69 SELT antibodies from over 11 suppliers available with over 16 conjugates.

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