PKC iota Monoclonal / Unconjugated / 1G11

Product Details
Description PRKCI - protein kinase C, iota
Conjugate Unconjugated
Clone 1G11
Target Species Human
Applications ELISA, ICC, IF, RNAi, WB
Supplier Novus Biologicals
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About PKC iota
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
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Validation References
PMID 22543584
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193 PKC iota antibodies from over 17 suppliers available with over 38 conjugates.

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