NGF Receptor/p75NTR (CD271) Monoclonal / Unconjugated / NGFR5

Product Details

Description	It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
Conjugate	Unconjugated
Clone	NGFR5
Target Species	Baboon, Feline, Ferret, Human, Monkey, Mouse (Negative), Rabbit, Rat (Negative)
Applications	IHC-P, IHC
Supplier	Novus Biologicals
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