Caspase 3 Monoclonal / Unconjugated / 84803
Product Details
| Description | Human Caspase-3 Antibody | |
|---|---|---|
| Conjugate | Unconjugated | |
| Clone | 84803 | |
| Target Species | Human | |
| Applications | Knockout Validated, WB | |
| Supplier | R&D Systems | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About Caspase 3
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
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Validation References
| PMID 16540654 | |
|---|---|
| PMID 16982628 | |
| PMID 17400600 | |
| PMID 17487982 | |
| PMID 24447339 | |
| PMID 24498154 | |
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