Niemann-Pick C1 Polyclonal / Alexa Fluor 405 /

Product Details
Description Rabbit Niemann-Pick C1 antibody [Alexa Fluor 405] detects Human, Mouse, Rat, Porcine, Chinese Hamster, Hamster, Primate
Conjugate Alexa Fluor 405
Clone
Target Species Chinese Hamster, Hamster, Human, Mouse, Porcine, Primate, Rat
Applications KD, Knockout Validated, ICC, IF, IHC-P, WB, IHC
Supplier Novus Biologicals
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About Niemann-Pick C1
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
About Alexa Fluor 405
Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to V450 (BD Biosciences), Vio®Blue® (Miltenyi Biotec), Cascade Blue® (ThermoFisher Scientific), Pacific Blue® (ThermoFisher Scientific). Alexa 405 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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