Neurofilament Heavy 200kDa Monoclonal / Alexa Fluor 647 / RNF405

Product Details
Description RNF405 reacts exclusively with the phosphorylated isoform of the 200 kD neurofilament protein.
Conjugate Alexa Fluor 647
Clone RNF405
Target Species Bovine, Canine, Chicken, Guinea Pig, Hamster, Human, Monkey, Mouse, Primate, Rabbit, Rat, Sheep, Xenopus, Zebrafish
Applications ICC, IF, WB, IHC-Fr, IHC
Supplier Novus Biologicals
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About Neurofilament Heavy 200kDa
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]
About Alexa Fluor 647
Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
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