CD25 / VioBright FITC / 4E3
Product Details
| Description | The CD25 antibody recognizes the human CD25 antigen, a 28 kDa glycoprotein, also known as the low-affinity interleukin-2 receptor alpha chain (IL-2Ralpha). CD25 is expressed on activated T and B cells, on macrophages, and on a subset of non-activated CD4+ regulatory T cells. | The CD25 antigen contains three epitope regions called A, B, and C. This CD25 antibody recognizes epitope region B. | |
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| Conjugate | VioBright FITC | |
| Clone | 4E3 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD25
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
About VioBright FITC
Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
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Validation References
| PMID 7636184 | |
|---|---|
| PMID 11390442 | |
| PMID 11526392 | |
| PMID 18684866 | |
| PMID 23525357 | |
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Reviews & Ratings
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3401 CD25 antibodies from over 54 suppliers available with over 168 conjugates.
