Nectin-4 Monoclonal / APC / REA967
Product Details
Description | Clone REA967 recognizes the human nectin-4 protein, also known as the poliovirus receptor-related protein 4 (PVRL4), a type I transmembrane adhesion glycoprotein of the Ig superfamily receptor LNIR. Nectin-4 is specifically expressed in placenta and on breast carcinoma cells. All nectins are known as receptors for the herpes simplex virus. | Additional information: Clone REA967 displays negligible binding to Fc receptors. | |
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Conjugate | APC | |
Clone | REA967 | |
Target Species | Human | |
Applications | FC | |
Supplier | Miltenyi Biotec | |
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About Nectin-4
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
PMID 11544254 | |
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PMID 15784625 | |
PMID 17474988 | |
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192 Nectin-4 antibodies from over 18 suppliers available with over 43 conjugates.