Ly-49A/Ly-49D Monoclonal / Biotin / REA853

Product Details

Description	Clone REA853 recognizes the mouse Ly-49A and Ly-49D antigens belonging to the Ly-49 family. Members of Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands, and include activating and inhibitory receptor molecules. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK T cells. Ly-49D is a prototypic activating member of Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12. \| Clone REA853 does not react with BALB/c, DBA/2, AKR, or CBA/J Ly-D49D. \| Additional information: Clone REA853 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA853
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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