CD49b Monoclonal / PE / REA981

Product Details
Description Clone REA981 recognizes the mouse and rat CD49b antigen, a transmembrane glycoprotein also known as integrin alpha-2 (Itga2). CD49 is found on activated lymphocytes, epithelial cells, and platelets. In association with CD29 (integrin beta-1), a VLA-2 complex is formed, which functions as a receptor for collagen and collagen C-propeptides, laminin, and E-cadherin. | Additional information: Clone REA981 displays negligible binding to Fc receptors.
Conjugate PE
Clone REA981
Target Species Mouse, Rat
Applications FC
Supplier Miltenyi Biotec
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About CD49b
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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Validation References
PMID 2188667
PMID 7521231
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