CD45 Monoclonal / PE-Vio615 / REA1023
Product Details
| Description | Clone REA1023 recognizes the rhesus monkey (Macaca mulatta) and cynomolgus monkey (Macaca fascicularis) CD45 antigen. It is reported to cross-react with pigtail monkey (Macaca nemestrina) and human. CD45 is a type I membrane glycoprotein also known as leukocyte common antigen (LCA), T200, or receptor-type tyrosine-protein phosphatase C (PTPRC). It is expressed on non-human primate hematopietic cells, such as lymphocytes, monocytes, and granulocytes. It is not found on erythroid cells. CD45 functions as a regulator for cell growth, differentiation, cell cycle, and oncogenic transformation. | Additional information: Clone REA1023 displays negligible binding to Fc receptors. | |
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| Conjugate | PE-Vio615 | |
| Clone | REA1023 | |
| Target Species | Non-Human Primate | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
About PE-Vio615
PE-Vio®615 from Miltenyi Biotec has an excitation peak at 565 nm and an emission peak at 619 nm. It is spectrally similar to PE-eFluor™ 610, PE-Dazzle 594 and PE-CF®594
PE-Vio®615 from Miltenyi Biotec has an excitation peak at 565 nm and an emission peak at 619 nm. It is spectrally similar to PE-eFluor™ 610, PE-Dazzle 594 and PE-CF®594
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