CD357 Monoclonal / APC / REA1007
Product Details
| Description | Clone REA1007 recognizes the human CD357 antigen, also known as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) or TNFRSF18, which is an inducible type I transmembrane protein and a member of the tumor necrosis factor receptor (TNFR) superfamily. CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, and macrophages, and at high levels on CD4+CD25+ regulatory T cells (Tregs). Upon activation, expression on CD4+ and CD8+ T cells is upregulated. Triggering of GITR has been described to modulate Treg function and co-stimulate effector T cells. Stimulation of T cells through GITR can abrogate the inhibitory function of Tregs. It is hypothesized that GITR has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that GITR activation may break self-tolerance and induce autoimmunity. | Additional information: Clone REA1007 displays negligible binding to Fc receptors. | |
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| Conjugate | APC | |
| Clone | REA1007 | |
| Target Species | Human | |
| Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD357
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
| PMID 9177197 | |
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| PMID 10074428 | |
| PMID 17407102 | |
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Reviews & Ratings
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