CD265 Monoclonal / Biotin / REA961
Product Details
| Description | Clone REA961 recognizes the mouse CD265 antigen, also known as receptor activator of NF-kappaB (RANK) or tumor necrosis factor receptor superfamily member 11A (TNFRSF11A). RANK is the receptor for RANK-ligand (RANKL) which promotes osteoclast differentiation and activation. CD265 is also expressed on dendritic cells, skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, mammary gland epithelial cells, prostate, vascular cells, and pancreas. | Additional information: Clone REA961 displays negligible binding to Fc receptors. | |
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| Conjugate | Biotin | |
| Clone | REA961 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD265
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
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Validation References
| PMID 9367155 | |
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| PMID 12185073 | |
| PMID 20483727 | |
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