CD183 Monoclonal / APC / REA874

Product Details

Description	Clone REA874 recognizes the rat CD183 antigen, also known as CXCR3. CD183 is a member of the CXC chemokine receptor family and is found on activated T cells, B cells, and NK cells during inflammation. CD183 plays a critical role in T cell migration and is important for activated T lymphoblast recruitment. It mediates the proliferation, survival, and angiogenic activity, and functions as a 7-transmembrane spanning receptor for the CXC chemokines CXCL9, CXCL10, and CXCL11. \| Additional information: Clone REA874 displays negligible binding to Fc receptors.
Conjugate	APC
Clone	REA874
Target Species	Rat
Applications	FC
Supplier	Miltenyi Biotec
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About CD183
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

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