CD122 Monoclonal / APC / REA1015
Product Details
Description | Clone REA1015 recognizes the murine CD122 70–75 kDa cell surface glycoprotein, also known as interleukin-2 receptor beta chain (IL-2Rbeta). CD122 is constitutively expressed on mouse NK cells and at a lower level on subsets of T cells, B cells, monocytes, and macrophages. CD122 can associate with the common gamma subunit (gammac, CD132) alone or with the gammac subunit and the IL-2Ralpha subunit (CD25), resulting in intermediate or high affinity IL-2 receptor complexes. CD122 expression levels can be upregulated by activation. Clone REA1015 interferes with binding of IL-2 to the receptor and can be used to deplete CD122+ cells. | Additional information: Clone REA1015 displays negligible binding to Fc receptors. | |
---|---|---|
Conjugate | APC | |
Clone | REA1015 | |
Target Species | Mouse | |
Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
Supplier | Miltenyi Biotec | |
Catalog # | Sign in to view product details, citations, and spectra | |
Size | ||
Price | ||
Antigen | ||
Host | ||
Isotype |
About CD122
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Experiment Design Tools
Panel Builders
Looking to design a Microscopy or Flow Cytometry experiment?
Validation References
PMID 1918958 | |
---|---|
PMID 7648447 | |
PMID 20460838 | |
PMID 22072559 | |
Additional Sources |
Reviews & Ratings
Reviews |
---|
Looking for more options?
882 CD122 antibodies from over 35 suppliers available with over 78 conjugates.