CD102 Monoclonal / PE-Vio770 / REA878
Product Details
Description | Clone REA878 recognizes the human CD102 antigen, a type I transmembrane glycoprotein with two immunoglobulin-like domains. CD102, also known as ICAM-2, is a member of the intercellular adhesion molecule (ICAM) family, that binds to leukocyte integrin, lymphocyte function-associated antigen-1 (LFA-1), dendritic cell-specific antigen, ICAM-grabbing non-integrin (DC-SIGN) protein and macrophage-1 antigen (MAC-1). CD102 is found on vascular endothelial cells, monocytes, platelets and different populations of lymphocytes.. | CD102 is involved in lymphocyte recirculation and induces essential adhesive cell interactions, which are important for immune response and surveillance. | Additional information: Clone REA878 displays negligible binding to Fc receptors. | |
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Conjugate | PE-Vio770 | |
Clone | REA878 | |
Target Species | Human | |
Applications | FC | |
Supplier | Miltenyi Biotec | |
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About CD102
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
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Validation References
PMID 2497351 | |
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PMID 7553659 | |
PMID 15673159 | |
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