Cadherin-6 Monoclonal / PE / REA846
Product Details
| Description | Clone REA846 recognizes the human cadherin-6 antigen, a type I membrane-associated glycoprotein also known as K-cadherin or KCAD, which is a member of the cadherin superfamily. Cadherin-6 is found in a high level in kidney, brain, and cerebellum. It is also expressed in renal and ovariancarcinoma and in a low level in lung, pancreas, gastric mucosa, and cytotrophoblasts. Cadherins are involved in cell adhesion, forming adherens junctions. This is mediated by extracellular domains of cadherins, whereas the intracellular cytoplasmic tail associates with different adaptor and signaling proteins. | Additional information: Clone REA846 displays negligible binding to Fc receptors. | |
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| Conjugate | PE | |
| Clone | REA846 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About Cadherin-6
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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Validation References
| PMID 10207020 | |
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| PMID 10861224 | |
| PMID 11171368 | |
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