CD155 Monoclonal / Biotin / PV404.19

Product Details

Description	Clone PV404.19 recognizes the human CD155 antigen, a single-pass type I membrane protein also known as poliovirus receptor (PVR) or nectin-like protein 5 (NECL-5). CD155 is composed of two Ig-like C2-type domains and one Ig-like V-type domain that is necessary for poliovirus binding and uptake. Four different isotypes (alpha to delta) exist, originated from alternate splicing of the CD155 mRNA. CD155 is a broadly expressed receptor which is, e.g., found on monocytes, a T cell subset, and neurons of the central nervous system. CD155 is also expressed on some CD34+ progenitor cells, particulary on progenitors committed in myeloid differentiation. It can interact with several ligands, such as CD226, TIGIT, CD96, vitronectin, integrin alphavbeta3, and PDGFR. The functions of CD155 include roles in cell adhesion, neural differentiation, and NK cell effector functions.
Conjugate	Biotin
Clone	PV404.19
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About CD155
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

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