CD140a Monoclonal / FITC / REA911

Product Details
Description Clone REA911 recognizes the human CD140a single transmembrane glycoprotein, also known as platelet derived growth factor (PDGF) receptor alpha. CD140 a is a tyrosine-protein kinase which functions as a cell-surface receptor for PDGFA, PDGFB, and PDGFC and is involved in the regulation of embryonic development, cell proliferation, survival, and chemotaxis. CD140a is found on platelets, fibroblasts, smooth muscle cells, glial cells, and chondrocytes as well as in brain, heart, embryo, colon tumors, and in normal colon tissues. | Additional information: Clone REA911 displays negligible binding to Fc receptors.
Conjugate FITC
Clone REA911
Target Species Human
Applications FC
Supplier Miltenyi Biotec
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About CD140a
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
About FITC
Fluorescein isothiocyanate (FITC) has an excitation peak at 495 nm and an emission peak at 519 nm. The name FITC is a misnomer in that the isothiocyanate is a reactive form of this dye. Once FITC is conjugated to an antibody, it is simply Fluorescein conjugated. FITC is one of the most widely used dyes for fluorescent applications, therefore most instruments come standard with a 488 nm laser and FITC filter set up. FITC is commonly conjugated to secondary antibodies and used in applications such as flow cytometry, immunocytochemistry, and immunohistochemistry. FITC is relatively dim, sensitive to photobleaching and it is susceptible to changes is pH. There are better performing alternatives to FITC, like Vio®Bright 515, Alexa Fluor™ 488, iFluor® 488, CF®488A and DY-488. FITC is a long-time generic dye with no sole manufacturer or trademark.
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