EphB4 Monoclonal / APC / REA923
Product Details
| Description | Clone REA923 recognizes the human ephrin type-B receptor 4 (EPHB4) antigen, which is a member of the Eph receptor tyrosine kinase family. The ligand for EPHB4 is ephrin-B2. EPHB4 is found in different tissues, e.g., in placenta, kidney, liver, lung, pancreas, skeletal muscle, and heart. It is expressed on myeloid hematopoietic cells and endothelial cells. EPHB4 functions as an inhibitor for cell-cell adhesion, chemotaxis, and angiogenesis as well as a promoter for the differentiation of megakaryocytic and erythroid progenitor cells. | Additional information: Clone REA923 displays negligible binding to Fc receptors. | |
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| Conjugate | APC | |
| Clone | REA923 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About EphB4
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
| PMID 12734395 | |
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| PMID 16424904 | |
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395 EphB4 antibodies from over 18 suppliers available with over 39 conjugates.
