CD355 Monoclonal / APC-Vio770 / REA882

Product Details

Description	Clone REA882 recognizes the mouse CD355 antigen, also known as class I MHC-restricted T cell associated molecule (CRTAM). CD355 is a type I immunoglobulin-superfamily transmembrane receptor, which is expressed by activated CD8+ T cells and NK cells, but it is also found on spleen, brain, and testis. CD355 recognizes nectin-like molecule 2 (Necl-2), a cell-surface protein that mediates epithelial cell junctions and interactions with other nectins and Necls. In association with Necl-2, CD355 promotes cytotoxicity of NK cells and IFN-gamma secretion of CD8+ T cells and NK cell–mediated rejection of tumors. \| Additional information: Clone REA882 displays negligible binding to Fc receptors.
Conjugate	APC-Vio770
Clone	REA882
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD355
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.

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