CLEC5A Monoclonal / PE / REA912

Product Details
Description Clone REA912 recognizes the human myeloid DAP12-associating lectin 1 (MDL-1) antigen, also known as CLECSF5 or CLEC5A. MDL-1 is a type II transmembrane protein belonging to the C type lectin superfamily. It is exclusively expressed in monocytes and macrophages. The association of DAP12 and MDL-1 is essential for the activation in myeloid cells. | Additional information: Clone REA912 displays negligible binding to Fc receptors.
Conjugate PE
Clone REA912
Target Species Human
Applications FC
Supplier Miltenyi Biotec
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About CLEC5A
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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Validation References
PMID 10449773
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