CD66e Monoclonal / APC / REA876

Product Details

Description	Clone REA876 recognizes the human CD66e antigen, a member of the immunoglobin superfamily which is also known as carcinoembryonic antigen (CEA) or CEA-related cell adhesion molecules 5 (CEACAM5). CD66e is GPI-linked glycosylated protein found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. CD66e and other CEACAMs are host receptors for the Dr family of adhesins of Escherichia coli. CD66e is an intercellular adhesion molecule and is able to inhibit cellular differentiation. The overexpression of CD66e is used as an indicator for tumor invasiveness. \| Additional information: Clone REA876 displays negligible binding to Fc receptors.
Conjugate	APC
Clone	REA876
Target Species	Human
Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Supplier	Miltenyi Biotec
	Catalog #	Sign in to view product details, citations, and spectra
	Size
	Price
	Antigen
	Host
	Isotype

About CD66e
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

Experiment Design Tools