Flamingo homolog 1 Monoclonal / Biotin / REA868

Product Details

Description	Clone REA868 recognizes the human CELSR3 antigen, a seven-transmembrane receptor protein, which contains an extended N-terminal extracellular region and a C-terminal cytoplasmic domain. CELSR3 belongs to the G-protein–coupled receptors (GPCR) family and to the flamingo subfamily, which is a part of the cadherin superfamily consisting of nonclassic-type cadherins, which does not interact with catenins. CELSR3 may plays a role in the regulation of contact-mediated communication. In tumor stellate cells CELSR3 were found to be selectively up-regulated. \| Additional information: Clone REA868 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA868
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About Flamingo homolog 1
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

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