CD202b Monoclonal / VioBright FITC / REA735

Product Details
Description Clone REA735 recognizes the CD202b antigen, also known as TIE-2 or TEK. CD202b is a tyrosine-protein kinase which is mainly expressed in endothelial cells and their progenitors. CD202b is a cell-surface receptor for angiopoietins and is involved in angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, and re-organization of the actin cytoskeleton. | Additional information: Clone REA735 displays negligible binding to Fc receptors.
Conjugate VioBright FITC
Clone REA735
Target Species Mouse
Applications FC
Supplier Miltenyi Biotec
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About CD202b
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
About VioBright FITC
Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
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