CD337 Monoclonal / PE-Vio770 / REA823

Product Details

Description	Clone REA823 recognizes the CD337 (NKp30) receptor, which is a 30 kDa type I membrane glycoprotein characterized by a single V-type Ig-like domain in the extracellular portion. CD337 is found almost exclusively on the surface of resting or activated natural killer (NK) cells and is a member of the natural cytotoxicity receptor (NCR) family which trigger cytotoxicity in NK cells. CD337 is directly involved in target cell recognition and lysis and is expressed by all resting or activated NK cells and by a small subset of T cells. Its expression density parallels that of CD336 (NKp44). It seems to be involved in killing of cells which are lysed independently from CD336 (NKp44) and CD335 (NKp46). \| Additional information: Clone REA823 displays negligible binding to Fc receptors.
Conjugate	PE-Vio770
Clone	REA823
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About CD337
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.

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