Cadherin-13 Monoclonal / PE / REA752

Product Details
Description Clone REA752 recognizes the human cadherin-13 antigen, also known as T-Cadherin or H-Cadherin (heart cadherin). Cadherin-13 is a transmembrane glycoprotein that mediates calcium-dependent intercellular adhesion. | It is suggested that cadherin-13 may function as a negative regulator of neural cell growth. Cadherin-13 is expressed human adult cerebral cortex, medulla, thalamus, and midbrain. In developing brain, a lower expression is found than in adult brain. Furthermore, cadherin-13 is expressed in the basal layer of the epidermis, lung, liver, kidney, and blood vessels. It is reported, that cadherin-13 could be used as a marker for breast cancer development. | Additional information: Clone REA752 displays negligible binding to Fc receptors.
Conjugate PE
Clone REA752
Target Species Human
Applications FC
Supplier Miltenyi Biotec
Catalog # Sign in to view product details, citations, and spectra
Size
Price
Antigen
Host
Isotype
About Cadherin-13
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Experiment Design Tools
Panel Builders

Looking to design a Microscopy or Flow Cytometry experiment?

Validation References
Reviews & Ratings
Looking for more options?

403 Cadherin-13 antibodies from over 23 suppliers available with over 42 conjugates.

Supplier Page
 Compare