CD207 Monoclonal / PE / REA770

Product Details
Description Clone REA770 recognizes the CD207 antigen, a 40 kDa glycosylated type II transmembrane C-type lectin receptor, and the standard marker for human and murine Langerhans cells (LCs). LCs are a subset of dendritic cells (DCs) that reside in epithelia; the best studied example of these antigen-presenting cells are LCs of the epidermis. CD207 is directly involved in antigen capture as well as endocytosis and induces the formation of typical Birbeck granules in immature DCs. | Additional information: Clone REA770 displays negligible binding to Fc receptors.
Conjugate PE
Clone REA770
Target Species Human
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Supplier Miltenyi Biotec
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About CD207
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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358 CD207 antibodies from over 27 suppliers available with over 52 conjugates.

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