XCR1 Monoclonal / Biotin / REA707

Product Details

Description	Clone REA707 recognizes the rat and mouse XCR1 antigen, also known as GPR5. XCR1 is a G protein–coupled chemokine receptor for XCL1 and XCL2, also known as lymphotactin-1 and -2. XCR1 is highly expressed in CD8alpha+ dendritic cells. It plays a role in signal transduction by increasing the intracellular calcium ions level. \| Additional information: Clone REA707 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA707
Target Species	Mouse, Rat
Applications	FC
Supplier	Miltenyi Biotec
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About XCR1
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2020]

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