CD28 Monoclonal / Biotin / REA806
Product Details
| Description | Clone REA806 recognizes the mouse CD28 antigen, a costimulatory molecule, expressed on most thymocytes, CD4+ and CD8+ T cells, and NK cells. Expression is down-regulated at late stages of terminal effector T cell differentiation. CD28 is a homodimeric type I transmembrane protein of the Ig receptor superfamily, composed of disulfide-linked 45 kDa subunits. Ligation of CD28 with CD80 (B7-1) and CD86 (B7-2) provides a costimulatory signal for T cell activation. | Additional information: Clone REA806 displays negligible binding to Fc receptors. | |
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| Conjugate | Biotin | |
| Clone | REA806 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD28
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
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Validation References
| PMID 1713603 | |
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| PMID 2157764 | |
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