Lag-3 Monoclonal / Biotin / REA776
Product Details
| Description | Clone REA776 recognizes an epitope within the D2 domain of murine CD233, also known as LAG-3, which is a 70 kDa high affinity MHC class II ligand. It is expressed on activated CD4+ and CD8+ alpha/beta T cells, on a subset of NK cells, B cells and plasmacytoid dendritic cells. It is proposed, that LAG-3 could be used as a marker of T cell induced B cell activation. | In association with the CD3 complex CD223 is a negative regulatory molecule to inhibit TCR-mediated signaling and to regulate homeostatic T cell expansion. | Additional information: Clone REA776 displays negligible binding to Fc receptors | |
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| Conjugate | Biotin | |
| Clone | REA776 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About Lag-3
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
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Validation References
| PMID 1380059 | |
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| PMID 12209638 | |
| PMID 12421911 | |
| PMID 15971272 | |
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