CD183 Monoclonal / VioBright FITC / REA724
Product Details
| Description | Clone REA724 recognizes the mouse CD183 antigen, also known as CXCR3, a 40 kDa seven-transmembrane protein belonging to the the G protein–coupled receptor family that mediates the proliferation, survival, and angiogenic activity of mesangial cells through a heterotrimeric G protein signaling pathway. CD183 binds the ligands CXCL9, CXCL10, and CXCL11 and mediates Ca 2)+ mobilization and chemotaxis. It is expressed on activated T cells, circulating blood T cells, B cells, and NK cells. | Additional information: Clone REA724 displays negligible binding to Fc receptors. | |
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| Conjugate | VioBright FITC | |
| Clone | REA724 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD183
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
About VioBright FITC
Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
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Validation References
| PMID 9653165 | |
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| PMID 9790904 | |
| PMID 21183079 | |
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Reviews & Ratings
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