RAMP2 Monoclonal / Biotin / REA703
Product Details
| Description | Clone REA703 recognizes the mouse RAMP2 antigen, a 20 kDa single-transmembrane-domain protein expressed in lung, breast, immune system, and fetal tissues. In interaction with the calcitonin receptor-like receptor (CRLR), a class B G protein–coupled receptor (GPCR), RAMP2 forms a heterodimer for adrenomedullin (AM). | Additional information: Clone REA703 displays negligible binding to Fc receptors. | |
|---|---|---|
| Conjugate | Biotin | |
| Clone | REA703 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About RAMP2
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]
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Validation References
| PMID 9620797 | |
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| PMID 22102369 | |
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196 RAMP2 antibodies from over 16 suppliers available with over 44 conjugates.
