CD64 Monoclonal / Unconjugated / 10.1
Product Details
Description | CD64 (FcgammaRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding alpha subunit and promiscuous gamma subunit, which is indispensable for tyrosine-based signaling. However, even the alpha subunit can transduce signals leading to cellular effector functions. The isoform FcgammaRIa1 binds human IgG with high affinity, has limited myeloid cell distribution, and a relatively large intracellular domain. Products of related genes include FcgammaRIb and FcgammaRIc isoforms, but these specify low affinity IgG receptors if functionally expressed at all. Besides a role in antigen clearance, FcgammaRI (a1) can potently enhance MHC class I and II antigen presentation in vitro and in vivo. | |
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Conjugate | Unconjugated | |
Clone | 10.1 | |
Target Species | Human, Non-Human Primate | |
Applications | FC, IHC-P, ICC, WB, IP, IHC-Fr | |
Supplier | EXBIO | |
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1073 CD64 antibodies from over 35 suppliers available with over 85 conjugates.