CD38 Monoclonal / PE-DyLight 594 / HIT2
Product Details
| Description | CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration. | |
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| Conjugate | PE-DyLight 594 | |
| Clone | HIT2 | |
| Target Species | Human | |
| Applications | FC, IHC-P, WB, IHC-Fr | |
| Supplier | EXBIO | |
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About CD38
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
About PE-DyLight 594
PE-DyLight™ 594 (PE-DY594) from Thermo Fisher Scientifichas an excitation peak at 565 nm and an emission peak at 618 nm, and is suitable alternative to PE-Texas Red, PE-eF610, PE-Alexa Fluor™ 610 or PE-CF®594.
PE-DyLight™ 594 (PE-DY594) from Thermo Fisher Scientifichas an excitation peak at 565 nm and an emission peak at 618 nm, and is suitable alternative to PE-Texas Red, PE-eF610, PE-Alexa Fluor™ 610 or PE-CF®594.
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2287 CD38 antibodies from over 54 suppliers available with over 162 conjugates.
