CD8 Monoclonal / Pacific Orange / MEM-31
Product Details
| Description | The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling. | |
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| Conjugate | Pacific Orange | |
| Clone | MEM-31 | |
| Target Species | Human | |
| Applications | FC, CyTOF, IP | |
| Supplier | EXBIO | |
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About Pacific Orange
Pacific Orange® (Pac Orange, PacOrange) is an orange-emitting organic fluorophore that can be excited by the 405 nm Violet laser and captured with a 585/42 nm bandpass filter. Pacific Orange has an excititaion peak at 400 nm and an emission peak at 551 nm.
Pacific Orange® (Pac Orange, PacOrange) is an orange-emitting organic fluorophore that can be excited by the 405 nm Violet laser and captured with a 585/42 nm bandpass filter. Pacific Orange has an excititaion peak at 400 nm and an emission peak at 551 nm.
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2845 CD8 antibodies from over 46 suppliers available with over 178 conjugates.
