CD8 Monoclonal / PE-DyLight 594 / MEM-31

Product Details
Description The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Conjugate PE-DyLight 594
Clone MEM-31
Target Species Human
Applications FC, CyTOF, IP
Supplier EXBIO
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About PE-DyLight 594
PE-DyLight™ 594 (PE-DY594) from Thermo Fisher Scientifichas an excitation peak at 565 nm and an emission peak at 618 nm, and is suitable alternative to PE-Texas Red, PE-eF610, PE-Alexa Fluor™ 610 or PE-CF®594.
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