CD140b Monoclonal / VioBright FITC / REA634

Product Details

Description	Clone REA634 recognizes the mouse CD140b antigen, also known as platelet-derived growth factor receptor-beta (PDGFR-beta), a tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB. CD140b plays a role in the regulation of embryonic development, cell proliferation, differentiation, chemotaxis, survival, and migration. CD140b is expressed on embryonic tissues and mesenchymal-derived cells in adult mice. \| Additional information: Clone REA634 displays negligible binding to Fc receptors.
Conjugate	VioBright FITC
Clone	REA634
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD140b
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]

About VioBright FITC
Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.

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