TCR V beta 2 Monoclonal / PE-Vio770 / REA654

Product Details

Description	Clone REA654 recognizes the human variable beta2 subunit of the alpha/beta T cell receptor (TCR Vbeta2). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The alpha and beta TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vbeta2 is a variant of the TCR beta chain. alpha/beta T cells express a diverse alpha/beta TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell–mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of alpha/beta T cell–mediated immunity and underpins MHC restriction. \| Additional information: Clone REA654 displays negligible binding to Fc receptors.
Conjugate	PE-Vio770
Clone	REA654
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.

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