CD66 / Brilliant Violet 786 / B1.1/CD66

Product Details
Description BV786 Mouse Anti-Human CD66
Conjugate Brilliant Violet 786
Clone B1.1/CD66
Target Species Human
Applications FC
Supplier BD Biosciences
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About CD66
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
About Brilliant Violet 786
Brilliant™ Violet 786 (BV786) is a far-red-emitting tandem fluorophore that can be excited by the 405 nm Violet laser and collected using a 780/60 bandpass filter. BV750 has an excitation peak at 405 nm and an emission peak at 786 nm. Due to its unique Stokes shift, few dyes have identical or near identical excitation and emission spectrums, but the nearest alternatives are Qdot® 800 and SuperBright 780 (ThermoFisher), and Brilliant™ Violet 785 (BioLegend). What's the difference between BV785 and BV786? BV785 is a BioLegend color, while BV786 is a BD Biosciences color, but they exhibit the same spectral properties. This dye exhibits a medium level of brightness and is most often used in flow cytometry. Older instruments may not be set up for a dye with such a large Stokes shift, however BV786 is especially well suited for spectral cytometers or sorters. This dye is part of the Brilliant™ Violet dye line of fluorescent polymers. Brilliant™ Violet 421 polymer is employed as the donor molecule in a series of tandem dyes with acceptor molecules emitting at various points across the visible light spectrum. The Brilliant™ Violet dyes are a superior alternative to QDot nanocrystals and similar to SuperNova dye from Beckman Coulter and StarBright dyes from Bio-Rad.
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