TIM-3 Monoclonal / Biotin / REA602
Product Details
| Description | Clone REA602 reacts with the mouse TIM-3 antigen, which is a Tʜ1-specific cell surface protein expressed by differentiated CD4+ Tʜ1 and CD8+ Tc1 cells and macrophages. It is absent on CD4+ Tʜ2 and CD8+ Tc2 cells. TIM-3 has been proposed to inhibit Tʜ1-mediated immune responses. TIM-3 absence enhances the severity of experimental autoimmune encephalomyelitis in mice. The interaction of TIM-3 and galectin-9 induces apoptosis of Tʜ1 cells. | Additional information: Clone REA602 displays negligible binding to Fc receptors. | | |
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| Conjugate | Biotin | |
| Clone | REA602 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About TIM-3
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
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Validation References
| PMID 11823861 | |
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| PMID 17069754 | |
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