CD86 Monoclonal / Biotin / 24F
Product Details
| Description | Clone 24F recognizes the rat antigen CD86, also known as B7-2, which is a member of the B7 family of costimulatory molecules. In addition to CD80 (B7-1) , CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). It is expressed by germinal center B cells and weakly expressed on antigen presenting cells, such as macrophages and dendritic cells. Its expression is upregulated on B cells through a variety of surface stimuli including LPS. CD86 plays a critical role in the early events of T cell activation and costimulation of naive T cells as well as autoantibody and TĘś2-mediated Ig production. | |
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| Conjugate | Biotin | |
| Clone | 24F | |
| Target Species | Rat | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
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Validation References
| PMID 7540940 | |
|---|---|
| PMID 9237108 | |
| PMID 9850164 | |
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