TCR gamma/delta Monoclonal / VioBlue / REA547

Product Details
Description Clone REA547 recognizes the rat TCRgamma/delta antigen. The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. It consists of an alpha- and a beta-chain (TCRalpha/beta) or a gamma- and a delta-chain (TCRgamma/delta). The gamma and delta TCR–chains are composed of constant and variable regions, each encoded by distinct gene segments. The gamma-chain forms either disulfide-linked or non-disulfide-linked heterodimers with the delta-subunit. The gamma/delta T cell receptor is present on a subset of T lymphocytes in peripheral blood. TCRgamma/delta is involved in the antigen recognition of tumor-associated antigens or bacterial antigens presented by MHC class I molecules. | Additional information: Clone REA547 displays negligible binding to Fc receptors.
Conjugate VioBlue
Clone REA547
Target Species Rat
Applications FC
Supplier Miltenyi Biotec
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About TCR gamma/delta
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the gamma locus are known to be incapable of encoding a protein and are considered pseudogenes. Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T cell leukemia and ataxia telangiectasia. [provided by RefSeq, Jul 2008]
About VioBlue
Vio®Blue® has an excitation peak at 400 nm and an emission peak at 455 nm, and is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), V450 (BD Biosciences), Alexa Fluor™ 405 (ThermoFisher), Pacific Blue (ThermoFisher Scientific) and ATTO 425 (AttoTec).
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